Kinetic Model of DNA Replication in Eukaryotic Organisms
نویسندگان
چکیده
منابع مشابه
Kinetic model of DNA replication in eukaryotic organisms.
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition. The model describes well a large amount of different data within a simple theoretical framework. This allows one, for the first time, to determine the parameters governing the DNA replication program in a e...
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Replication of the two template strands at eukaryotic cell DNA replication forks is a highly coordinated process that ensures accurate and efficient genome duplication. Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. At least two differe...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2002
ISSN: 0022-2836
DOI: 10.1016/s0022-2836(02)00522-3